Making Platelets from Fat
and Inventing New Blood Supply System.

An aging society is a blood-deprived society. Aging means more elderly people who need blood. Aging means fewer young people who donate blood. The trend of increased demand and decreased supply of blood will even accelerate. Among the cells in blood, platelets are particularly important, helping stop bleeding and repairing tissue.

We, AdipoSeeds, invented a novel technology of making platelets from mesenchymal stem cells without a complex and costly gene transfer. With that technology, making platelet from fat tissue is now possible. The aims of AdipoSeeds are to solve the shortage of platelets in the world, and to create the future where a platelet-related treatment will be cheaply and safely provided.

Making Platelets from Fat and Inventing New Blood Supply System.

We are AdipoSeeds.

The mechanism of making platelets from fat tissue

Human fat tissue

isolation

Fat tissue is obtained through liposuction. Stable supply is possible.

ASC

(Fat-derived mesenchymal stromal/stem cells)

purification/cell line

Gene transfer is not required to establish the cell line (ASCL). Without a complex and costly method, we realize the safe and stable cell culture system.

ASCL

(Plenty of mesenchymal stem cells)

differentiation

ASCL, made from the fat tissue, is a mesenchymal stem cell which meets the criteria of International Society for Cellular Therapy. It can be safely frozen and thawed, and suitable for long-term preservation.

Megakaryocytes

release

With newly invented technology, mesenchymal stem cells are differentiated into platelets.

Platelets

(ASCL-PLC)

Fat-derived platelets are used to blood products and wound care medicine.

Regenerative medicine products

3 Key Points

Without Gene Transfer

We invented a novel technology of making platelets from mesenchymal stem cells without a complex and costly gene transfer.
From Subcutaneous Fat Tissue

Mesenchymal stem cells, the source of platelets, are indeed taken from fat tissue through liposuction.
Safety and Cost effective

It means, therefore, platelets can be made from the cells which are obtained in a safe, stable and inexpensive manner.

Usage

Provided in a safe, stable and inexpensive manner without blood donation, fat-derived platelets will be used not only for chemotherapy-induced thrombocytopenia (low platelet count), but also in the area of surgery or dentistry as they also help wound healing.

Company Name: AdipoSeeds, Inc.
Main Office: Yamato Bldg. 8F,
5-27-3, Sendagaya, Shibuya-ku, Tokyo,
151-0051, Japan
GoogleMap
Shinanomachi Lab: Keio University,
School of Medicine, Research Park 9N2,
35 Shinanomachi, Shinjuku-ku, Tokyo,
160-8582, Japan
GoogleMap
TEL: +81-03-6822-0325
Founded: July 7, 2016
Fiscal Year End: March
Capital: JPY 419,000,000 (as of Jul 2024)

Management

Scope of Business: Technology licensing to research partners in order to put human cell therapy products from far-derived cells into practical use

Junji Fuwa

CEO&CFO
U.S. CPA

Worked for Nippon Credit Bank (current Aozora Bank), HuBit genomix, Inc. which is a genomic research company, finance and administration positions of the companies invested by the buyout fund. Joined AdipoSeeds in January 2021. Appointed as the CEO&CFO of AdipoSeeds in June 2022.

Yumiko Matsubara

CSO & Founder
Ph. D. of Medicine Science (Keio University)
Visiting Professor, Institute for Integrated Sports Medicine, School of Medicine, Keio University

Main Research Theme:
Platelet Physiology Manufacturing platelets from adipose-derived mesenchymal stem cells

Scientific Society:
Japanese Society Hematology (Representative）,
Japanese Society on Thrombosis and Hemostasis (Representative)
American Society of Hematology,
International Society on Thrombosis and Hemostasis,
Japanese Society for Regenerative Medicine

Shigeki Hijikata

COO

Worked for Kaken KAKEN PHARMACEUTICAL CO., LTD., and had extended experiences including R&D management, sales, marketing, business development, etc. Joined AdipoSeeds in August 2021.

Tomokatsu Hongo

Outside Director
Ph. D. of Engineering (Nagoya University）

After working for Summit Pharmaceuticals International Corporation from 1999, he joined Keio Innovation Initiative, Inc. as a corporate officer in May 2016.

Norihide Hayakawa

Outside Director

After working for Yakult Honsha Co., Ltd. from 2012, he joined DCI Partners Co., Ltd. as a director officer in January 2019.

Yoshiyuki Jojima

Audit & Supervisory Board Member

Worked for JALUX, Inc. through key senior positions, JANPARA Co., Ltd. as the full-time auditor, FIMECS, Inc. as the full-time auditor. Appointed as the full-time auditor of AdipoSeeds in July 2024.

Hidetaka Itahashi

Audit & Supervisory Board Member

Worked for Sumitomo Mitsui Banking corporation holding key senior positions, Mazda Auto Leasing Company as the President ＆ CEO, NEC Capital Solutions as the President ＆ CEO and DYNAM as the Audit ＆ Supervisory Board Member. Appointed as the auditor of AdipoSeeds in June 2022.

Shizu Machino

Audit & Supervisory Board Member
Attorney at Law (Japan), Attorney at Law (New York)

Registered as a lawyer in 2007 and worked for Kitahama Partners. After working as a guest attorney at Masuda, Funai, Eifert & Mitchell, Ltd., she joined Innoventier LPC and became a partner in 2019. Appointed as the auditor of AdipoSeeds in Dec 2024.

Yasuo Ikeda

Audit & Supervisory Board Member
M.D, Ph. D. of Medical Science（Keio University）
Professor Emeritus, Keio University (former Dean of Medicine)
Specially Appointed Professor, Waseda University
Headmaster, Musashi Academy of the Nezu Foundation

He had successive posts of Keio University as Assistant Professor of Center for Blood Transfusion, Professor of Internal Medicine, Head of Center for Integrated Medical Research, Dean of Medicine, etc. He received the Showa Emperor Memorial Academic Award to appreciate his long-term contribution to the platelet study in 2019.

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Making Platelets from Fatand Inventing New Blood Supply System.

The mechanism of making platelets from fat tissue

3 Key Points

Usage

Making Platelets from Fat
and Inventing New Blood Supply System.