AdipoSeeds' business is based on the proprietary technologies; (1) establishment of ASCL (Adipose-derived Mesenchymal Stem Cell Line) from ASC (Adipose-derived Mesenchymal Stem Cell) in order to overcome the disadvantages of ASC which is isolated from human subcutaneous adipose tissues and (2) differentiation of ASCL into ASCL-PLC (Adipose-derived Mesenchymal Stem Cell Line-derived Platelet Like Cells).
Our founder and CSO, Dr. Yumiko Matsuhara, and her colleagues, discovered for the first time worldwide that ASC has the ability to differentiate into platelets while being non-hematopoietic cells, and elucidated the mechanism through a long-standing study on platelets.
This finding indicates that platelet production can be achieved by a simple cell culture method without introducing foreign genes using ASC as seed materials. This provides a scientific basis for the low-cost production of safe and medically applicable platelets.
Based on these technologies, we are doing two businesses: (1) a business that develops ASCL-PLC and/or ASCL as regenerative medicine products and (2) a business for PRP therapy (Platelet Rich Plasma therapy which is treatment for tissue restoration using platelets).
1
Regenerative medicine product development business
We are developing ASCL-PLC and/or ASCL as allogeneic regenerative medicine products with the aim of obtaining Manufacturing and sales approval for the Pharmaceuticals and Medical Devices Law.
ASCL-PLC has not only the function of hemostasis but also the higher ability to promote restoration and regeneration of tissue than platelet derived from peripheral blood because ASCL-PLC Inherits the characteristics of mesenchymal system cell.
Indication
Refractory Chronic Skin Ulcer, Platelet Transfusion, Tendon Lesion, etc.
Pipeline under development
Pipeline
ADS-01
Refractory Chronic Skin Ulcer
ADS-02
Platelet Transfusion
Hepatopathy
Osteoarthritis
Others
Modality
ASCL-PLC
ASCL-PLC
ASCL
ASCL
ASCL
ASCL-PLC
Basic Research
Applied Research
Pre-Clinical
Clinical Trial
Application for Approval
2
PRP business
AdipoSeeds has launched to provide the technical support of PRP therapy by Keio University Hospital since 2024. PRP therapy is developed based on the ability of platelets to repair tissue. Platelets are extracted from patient's own blood and injected into the affected area.
Cytokines included in platelets and their functions
PDGF
Platelet-Derived Growth Factor
Proliferation of fibroblast, vascular smooth muscle cell, etc.
Tissue Repair
TGF-β
Transforming Growth Factor-β
Control of cell proliferation and differentiation
Promotion of apoptosis
Control of inflammatory and immunity function
bFGF
basic Fibroblast Growth Factor
Proliferation of mesenchymal stem cell
Protection of nerve cell
Tissue Repair
VEGF
Vascular Endothelial Growth Factor
Proliferation of vascular endothelial cell
Tube formation
EGF
Epidermal Growth Factor
Proliferation of epithelium cell
